The USS McIlhatten in 2385
It was selected by Captain Jean-Luc Picard to serve in a Starfleet blockade of the Klingon-Romulan border during the Klingon Civil War in 2368. It served as a focal point and anchor in the tachyon detection grid, as it was linked to twelve other starships during the grid's initial deployment.
In 2385, the USS McIlhatten participated in the battle against the Xindi-Suliban Alliance at Kaleb IV. It engaged the attacking Xindi-Reptilian command ship, alongside the USS Juliano, to rescue the USS Fonseca, which was taking heavy fire.