The technical specifications of these weapons were classified under Starfleet Security Directive 24168.9. However, what was known was that they made use of a portable magnetic charge inducer which fired a beam of isomagnetic energy that disrupted a targets electromagnetic field. The effects depended entirely on the setting being used as a low setting stunned a target by targeting their inner ear while a moderate setting cause a temporary imparement of the central nervous system and the highest setting turning a target into dust as well as static by changing its protonic charge.
In 2375, isomagnetic disintegrators were part of the armory of the Sovereign-class USS Enterprise-E. Captain Jean-Luc Picard took ten isomagnetic disintegrators on his mission to help the Ba'ku resist forced resettlement. Lieutenant Commander Worf used one of the disintegrators to great effect against a pursuing landing team sent by the Son'a. A single hit to a rock near the four soldiers caused a heavy stun effect to all of them and some minor shrapnel damage from the stone fragments of the exploded rock.